TECHNOLOGY

INNITIUS is an In-vivo direct diagnostic technology based on the study of materials shear mechanical properties using  torsional ultrasound in order to understand and diagnose pathologies that manifest by tissue consistency changes.

TORSIONAL ULTRASOUND

Torsional waves are a spatial distribution of shear waves that propagate through solid and semi-solid media, so the measurement of the speed of sound in this type of media can be very useful to measure its structural characteristics.

Materials such as soft tissues or gels have the distinction of having well-differentiated compressibility and shear modulus. Due to the composition of these materials both S and P waves can propagate, nevertheless the difference in magnitude can cause the generation of spurious P waves that predominate, which consequently masks S waves, making it difficult in the commercial devices to read the S waves, which are the ones that really provide information about the shear modulus.

The technology that we have developed, capable of emitting and receiving torsional waves allows us, from the perspective of solid mechanics, to identify consistency changes (directly related to the rearrangement of the collagen matrix distribution) in tissues being useful to anticipate events related to delivery before other diagnostic techniques. More information about how torsional waves works:

icono-fine
FINE BIRTH WAS DESIGNED TO OBJECTIVIZE HOW THE VARIATIONS OF CERVICAL TISSUE MECHANICAL PROPERTIES, DIRECTLY RELATED TO EVENTS ASSOCIATED WITH THE DELIVERY.
On Preterm delivery, Cervical length (cl) <25 mm measured with transvaginal ultrasound (technique known in practice as cervicometry) mid-gestation is a known risk factor for sPTB. However, its value for screening a whole population of pregnant women consisting mainly of women without risk factors for sPTB remains controversial due to the low sensitivity of the technique At Induction labor, the main used technique is the Bishop’s test, which consists in the classification into a scale from 1 to 3 (hard> medium> soft) of the cervix tissue consistency through digital palpation of it by the gynecologist, being a technique highly dependent on the specialist.

CURRENT DIAGNOSTIC ALTERNATIVES

Nowadays, a wide number of technologies which focus on Preterm birth and induction labor success probabilities diagnosis have come to market to overcome classical techniques limitations. We can divide them into (1) in-vitro diagnostic tech. and (2) in-vivo diagnostic tech.

IN-VITRO

In-vitro diagnostic technologies

Based on the certain protein blood concentration analysis. They have a high NPV and PPV but anticipation to the issue is relatively insufficient. Additionally, cost per test is high for their application as a protocol pregnancy test at Public Health Systems.

IN-VIVO

In-viVo diagnostic technologies

Based on how cervix tissue properties change during the pregnancy process. Against in-vitro diagnostics, they have lower cost per test, test results are faster than with in-vitro assays. As counterpart, NPV and PPV are lower than in-vitro. These technologies can divide themselves into indirect techniques and direct techniques.

IN-VIVO

direct techniques

Direct techniques study the elastic properties of the tissue, which are related to stiffness. In this group, quantitative elastography stands out, a method based on the relation between wave velocity and tissue density. There are certain advantages that are positioning them in a key point in the market: fast measurement and low cost, in conjunction with an ultrasound scan allow to refine the diagnosis, it is also possible the monitoring and subsequent prognosis.

IN-VIVO

Indirect techniques

Indirect techniques analyze the mechanical behavior of the tissue according to certain interrelated biomechanical factors, such as electrical impedance, light scattering and absorption, ultrasonic attenuation or length of the cervical canal. However, these techniques are susceptible to misdiagnosis due to the lack of standardization, the existence of several algorithms and variations in range.