INNITIUS is an In-vivo direct diagnostic technology based on the study of materials shear mechanical properties using torsional ultrasound in order to understand and diagnose pathologies that manifest by tissue consistency changes.
Torsional waves are a spatial distribution of shear waves that propagate through solid and semi-solid media, so the measurement of the speed of sound in this type of media can be very useful to measure its structural characteristics.
Materials such as soft tissues or gels have the distinction of having well-differentiated compressibility and shear modulus. Due to the composition of these materials both S and P waves can propagate, nevertheless the difference in magnitude can cause the generation of spurious P waves that predominate, which consequently masks S waves, making it difficult in the commercial devices to read the S waves, which are the ones that really provide information about the shear modulus.
The technology that we have developed, capable of emitting and receiving torsional waves allows us, from the perspective of solid mechanics, to identify consistency changes (directly related to the rearrangement of the collagen matrix distribution) in tissues being useful to anticipate events related to delivery before other diagnostic techniques. More information about how torsional waves works:
CURRENT DIAGNOSTIC ALTERNATIVES
Nowadays, a wide number of technologies which focus on Preterm birth and induction labor success probabilities diagnosis have come to market to overcome classical techniques limitations. We can divide them into (1) in-vitro diagnostic tech. and (2) in-vivo diagnostic tech.
In-vitro diagnostic technologies
Based on the certain protein blood concentration analysis. They have a high NPV and PPV but anticipation to the issue is relatively insufficient. Additionally, cost per test is high for their application as a protocol pregnancy test at Public Health Systems.
In-viVo diagnostic technologies
Direct techniques study the elastic properties of the tissue, which are related to stiffness. In this group, quantitative elastography stands out, a method based on the relation between wave velocity and tissue density. There are certain advantages that are positioning them in a key point in the market: fast measurement and low cost, in conjunction with an ultrasound scan allow to refine the diagnosis, it is also possible the monitoring and subsequent prognosis.
Indirect techniques analyze the mechanical behavior of the tissue according to certain interrelated biomechanical factors, such as electrical impedance, light scattering and absorption, ultrasonic attenuation or length of the cervical canal. However, these techniques are susceptible to misdiagnosis due to the lack of standardization, the existence of several algorithms and variations in range.